This mutation activates the PTEN/PI3K/Akt signaling pathway and alters the levels of various molecules involved in preventing cell death (such as CASP-9, CASP-7, DFF-45, NPM, YWHAZ, Src, PAX2, MAPK8), promoting cell growth, and advancing cancer (like CDK1, CDK2, CDK8, CHEK1, CHEK2, GSK-3β, NPM, PAK1, PP2C-α) (Figure 3c) [49]. Here, NPM1 is linked to cancer.