TNFSF11 and periodontitis: This study demonstrated that the complex of xOC-STAMP-siRNA and C12-GD-Spe could significantly downregulate RANKL-induced osteoclastogenesis in vitro and that local injection of xOC-STAMP-siRNA/C12-GD-Spe complex could attenuate bone resorption induced in a mouse model of periodontitis.