Inhibition of the poly(adenosine diphosphate [ADP]–ribose) polymerases (PARPs), which are involved in single-strand break repairs, in neoplasms with BRCA1/2, ATM and CHEK2 mutations causes single- and double-strand breaks at the replication forks which will, eventually, lead to the disassembly of the replication fork and, consequently, cell cycle arrest [87,105,106,107]. This evidence concerns the gene ATM and neoplasm.