Torin increased autophagic flux in CHM−/− iPSC-RPE more than control iPSC-RPE cells (3.6-fold vs. 1.2-fold, p < 0.0001), thus supporting the role of mTOR signaling in reducing autophagic flux in choroideremia (Figure 5D,E). The gene discussed is PRDX2; the disease is choroideremia.