BDNF and Huntington disease: Additionally, thirty-six miRNAs have been identified and associated with at least one of the KEGG pathways relevant to HD, including apoptosis, cellular senescence, ubiquitin-mediated proteolysis, and signaling pathways such as neurotrophin, p53, ErbB, Notch, MAPK, AMPK, PI3K-Akt, mTOR, Wnt, and Hippo.