WWTR1 and cancer: The Hippo signaling pathway is dysregulated in a variety of cancers, leading to YAP/TAZ activation, which, in turn, leads to the hyperproliferation of cancer cells, a lack of apoptosis and stem cell maintenance, the epithelial-to-mesenchymal transition and increased invasion, metastatic potential, oxidative stress, and, finally, resistance to therapies [8,56] (Figure 2).