Pathways relating to MAPK signalling, PI3K-Akt signalling, Hippo signalling, Wnt signalling, focal adhesion, apoptosis, cellular senescence, and regulation of the actin cytoskeleton are relevant to POAG pathogenesis and are listed in Table S4 (significantly up-regulated miRNAs) and Table S5 (significantly down-regulated miRNAs) along with the associated miRNAs and gene targets. This evidence concerns the gene AKT1 and open-angle glaucoma.