In this study, we have treated human primary TM cells with either TGFβ1 or TGFβ2, as cellular models of POAG (TGFβ2) and XFG (TGFβ1), and using small RNA sequencing, we identified 186 TGFβ1-regulated miRNAs in TM cells and 72 TGFβ2-regulated miRNAs suggesting TGFβ1 stimulation had a stronger effect on the miRNA expression profile in TM cells. This evidence concerns the gene TGFB2 and open-angle glaucoma.