Additionally, it boosted the effectiveness of 5-fluoruracil (5-FU) in the invasive behaviour of colorectal cancer cells by increasing E-cadherin levels and suppressing the enzymatic activity of MMP-9 [98], suppressing c-Myc expression in osteosarcoma cells, enhancing immune effectors (IFNγ+CD8+ cells and NK cells), and reducing the number of immune suppressors (M2-like TAMs, MDSCs) in the tumour microenvironment [99]. Here, MMP9 is linked to neoplasm.