One more interaction with TGF-β is performed with the use of a bifunctional fusion protein targeting TGF-β and PD-L1—Bintrafusp alfa, which is used also in many solid tumours such as non-small cell lung cancer [128], head and neck cancer [129], and HPV-positive solid tumours [130]. The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.