In the combined analysis, the PTCH1 gene was overexpressed in BCC tissue by FC = 4 (95% CI 2.2–7.2) compared to healthy skin tissue (see Supplementary Table S3); but, in the absence of any non-synonymous somatic mutation in PTCH1 in BCC tissue (n = 14), the FC was 2.8 (95% CI 1.5–5.3), and in presence of a non-synonymous somatic mutation in PTCH1 in the BCC tissue (n = 12), the FC was 6 (95% CI 3.1–11.8) (interaction p = 0.03, see Table 2). This evidence concerns the gene PTCH1 and skin basal cell carcinoma.