Compared to healthy skin tissue, in the BCC samples without the PTCH1 non-synonymous somatic mutation (n = 14), the genes in the “Basal cell carcinoma pathway” were overexpressed by FC 1.62 (95% CI 1.34–1.96), whereas in BCC samples with the PTCH1 non-synonymous somatic mutation (n = 12), the same pathway genes were overexpressed by FC 3.95 (95% CI 3.24–4.82). The gene discussed is PTCH1; the disease is skin basal cell carcinoma.