Simultaneously, 3-formylchromone inhibits the expression of Bcl-2, Bcl-xL, Survivin, and Mcl-1 in liver cancer cells, suggesting that 3-formylchromone promotes apoptosis in liver cancer cells by suppressing the STAT3 pathway and weakening CXCL12-driven metastasis [70]. This evidence concerns the gene CXCL12 and liver cancer.