Synthetic triterpenoids have been found to inhibit the infiltration of tumor-associated macrophages into the mammary glands of PyMT mice, reduce the levels of chemokines CXCL12 and CCL2 in primary PyMT mammary tumor cells, and inhibit the phosphorylation of STAT3, thereby suppressing cell proliferation [167]. The gene discussed is CXCL12; the disease is breast cancer.