Crosstalk between the CXCL12/CXCR4/ACKR3 axis and the STAT3 signaling pathway has been hypothesized on the basis of findings that both the CXCL12/CXCR4/ACKR3 axis and STAT3 signaling pathway are involved in the progression of several cancers. Here, CXCR4 is linked to cancer.