Similarly, in gastric cancer, activation of the CXCL12/CXCR4 axis via the STAT3 pathway induces downregulation of E-Cadherin and upregulation of N-Cadherin, Vimentin, and Snail, enhancing EMT, migration, and the invasiveness of gastric cancer cells [85]. This evidence concerns the gene CDH1 and gastric cancer.