Specifically, fate-mapping experiments revealed that a fraction (10–25%) of OPCs acquire features of astrocytes (e.g., expression of the glial cell fibrillary protein (GFAP), or the Cx43, Aqp4, and Kcnq4 (Potassium Voltage-Gated Channel Subfamily KQT, Member 4) mRNAs and ion currents pattern similar to that observed in cortical astrocytes) upon cerebral stroke, cortical stab wound, SCI and experimental autoimmune encephalomyelitis (EAE) [61,62,63]. This evidence concerns the gene KCNQ4 and experimental autoimmune encephalomyelitis.