Quantitative mass spectrometry analysis of UM tumors has uncovered specific histone post-translational modifications (PTMs) associated with BAP1 status, as well as tumor stage and grade, such as increased levels of H3K4me1, peptides with H3K9me3, histone H3 27-40 with K36me2 and K27 methylations, multi-acetylated H4 tails, and H4K20me3 [196]. The gene discussed is BAP1; the disease is neoplasm.