This region also harbors a missense variant in coiled-coil domain-containing protein 92 (CCDC92), also known as Limkain beta-2, which is implicated in cardiac tissue damage and associated with coronary artery diseases, as well as a reduction in paired related homeobox 1 (PRRX1) expression that contributes to AF. Here, PRRX1 is linked to atrial fibrillation.