Malignant prostate epithelial cells of African American men revealed greater expression of tumor-promoting genes such as Tim-3 (T-cell immunoglobulin domain and mucin domain-containing molecule 3), PAI-1 (Plasminogen activator inhibitor-1), AR and PD-L1, while downregulation of basal cell markers such as p63 and KRT5 as compared to normal CR cells. The gene discussed is SERPINE1; the disease is neoplasm.