ROCK1 and osteonecrosis: For example, circRNA_ circ_0006859 was found to inhibit osteogenesis and promote adipogenesis in human in human bone marrow mesenchymal stem cells by targeting the signaling miR-431-5p/Rho-associated protein kinase 1 (ROCK1) [67] and circRNA-CDR1 promotes adipogenesis and inhibits osteogenic differentiation in osteonecrosis of the femoral head [68].