GZMB and neoplasm: Combined treatments of ApoE peptide-coated polymers capsulating the cytolytic enzyme granzyme B (ApoE-PS-GrB) and immune-stimulating CpG oligonucleotides (ApoE-PS-CpG) were used to induce immunogenic cell death (ICD) of the targeted cells and stimulate the maturation of dendritic cells within the tumor (Figure 2B).