The results showed that IL-2 (P ═ 0.002), IL-6 (P ═ 0.036), IL-10 (P ═ 0.022), IL-12p70 (P ═ 0.042), and IFN-α (P ═ 0.001) were significantly negatively correlated with the positive expression of p16 in tumor tissue; IL-2 (P ═ 0.039) was significantly negatively correlated with positive expression of p63 in tumor tissue; IL-8 (P ═ 0.028) was significantly positively correlated with the expression of Ki-67 in tumor tissue; the level of IFN-α (P ═ 0.013) is significantly positively correlated with the CPS index of PD-L1in peripheral blood. The gene discussed is IL6; the disease is neoplasm.