Among these, Interleukin (IL)-6 (P ═ 0.021) was highly expressed in laryngeal tumors, and the expression levels of IL-1β (P ═ 0.008), IL-6 (P ═ 0.005), and IL-8 (P ═ 0.05) were higher in patients with poorly differentiated laryngeal tumors. This evidence concerns the gene IL6 and laryngeal neoplasm.