As a result of the judicious selection of electrode design, it is possible to detect sepsis biomarkers with unprecedented sensitivity, reaching LODs of 0.82 ag mL−1 for PCT, 0.167 ng mL−1 for CRP, 0.202 pg mL−1 for TNF-α, and 0.056 fg mL−1 for IL-6. Here, TNF is linked to Sepsis.