Exposure to fine particulate matter (PM2.5 and PM10) has been consistently associated with increased production of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukins (IL-1β, IL-6, IL-8), and granulocyte–macrophage colony-stimulating factor (GM-CSF), contributing to systemic inflammation and increased risk of cardiovascular and respiratory diseases [22]. The gene discussed is TNF; the disease is respiratory system disorder.