In the present systematic review and meta-analysis, we summarised the evidence for breast cancer-specific survival and discovered 13 out of 22 significant prognostic factors including surgery, estrogen receptor status, education, histology, body mass index, HER2 receptor status, race, tumour size, tumour differentiation, age, grade, node affected, comorbidity index, and cancer staging. The gene discussed is ESR1; the disease is cancer.