GSTM1 and colorectal carcinoma: Subgroup analysis demonstrated that FIT was effective in ruling out SBD in the following conditions: with cut-off values 10 μg Hb/g, when the definition of SBD was CRC, HRA, or IBD, when using FIT alone, and in primary care; we believe that FIT could be instrumental in assisting GPs in excluding patients with potential SBD in primary care.