The de novo serine synthesis pathway (SSP; Figure 1) plays a crucial role in tumor metabolic adaptation and carcinogenesis and is mediated by phosphoglycerate dehydrogenase (PHGDH).4 The prognostic value of PHGDH has been shown in multiple cancers,5 yet little is known about its role in HGSOC. The gene discussed is PHGDH; the disease is neoplasm.