HIF1A and hereditary clear cell renal cell carcinoma: We used a genome-wide occupancy analysis of HIF1α from the public ChIP-seq database (ChIP-Atlas), which revealed significant peak enrichment of HIF1α in the annotated HIF1A-AS2 regulatory region (chr14:61,750,983-61,751,355) in different cell lines, including the human umbilical vein cell line (EA.hy926), human prostatic adenocarcinoma cell (PC3), human renal cell carcinoma cell line (RCC4), and human squamous cell carcinoma of the hypopharynx (FaDu; Fig. 2A).