GEM and cancer: Among IPA’s preconstructed pathways, the 14-3-3-mediated pathway, cancer drug resistance pathway, AMPK signaling pathway, adipogenesis pathway, 3-phosphoinositide biosynthesis pathway, aryl hydrocarbon receptor signaling pathway, 4-1BB signaling in T lymphocytes, and acute myeloid leukemia signaling pathway were all found to be significantly different between the two cell lines and potentially involved in Gem resistance (Table 3).