Immune response in patients with acute appendicitis includes increased neutrophil and C-reactive Protein (CRP).15,16 During pregnancy, there is evidence of increased neutrophil activation, but its activity and phagocytosis function are limited.17 In conclusion, decreased activities of activated neutrophils in pregnancy may explain higher rates of infectious complications, such as sepsis, in the pregnant population. The gene discussed is CRP; the disease is Sepsis.