SREBF1 and fatty liver disease: This gains significant importance as recent research has shown that ELOVL5 knockout (Elovl5−/−) mice developed hepatic steatosis via overactivation of sterol regulatory element-binding protein 1c (SREBP-1c) and its target genes (e.g., acetyl-CoA carboxylase–ACC and fatty acid synthase–FAS) involved in intracellular FAs synthesis (Moon et al., 2009).