FADS1 and obesity due to melanocortin 4 receptor deficiency: Consistently, Yashiro’s research group demonstrated that the use of a selective FADS1 inhibitor prevented obesity development in HFD-fed mice (Yashiro et al., 2016), whereas, another study showed that FADS1 gene knockout (fads−/−) mice exhibited improved glycemic parameters and resistance against obesity induction under HFD-feeding conditions (Powell et al., 2016).