In accordance, the mice lacking ELOVL3 (Elovl3−/−) developed by Zach-Avec and coworkers (Zach-Avec et al., 2010) were resistant to the induction of obesity by an HFD, which was associated with a reduced FAs uptake and inhibited de novo synthesis. The gene discussed is ELOVL3; the disease is obesity due to melanocortin 4 receptor deficiency.