MMP9 and obesity due to melanocortin 4 receptor deficiency: Moreover, we also have found that CBG inhibits the fibrotic muscular remodeling during the obesity state, which was revealed by a significant upregulation of secreted matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9) as well as collagen type 1, and type 3 (COL-1A1 and COL-3A1) expression, which contributes to the regulation of extracellular matrix turnover and probably may increase the regenerative capacity of the skeletal muscles.