These AA-derived metabolites are endogenous ligands of CB1 and CB2 receptors, and according to the current state of knowledge, overactivation of the CB1 receptor is closely related to the induction of the inflammatory response and occurrence of obesity (Silvestri and Di Marzo, 2013; Bielawiec et al., 2020). This evidence concerns the gene CNR1 and obesity due to melanocortin 4 receptor deficiency.