PTGS2 and obesity due to melanocortin 4 receptor deficiency: Not surprisingly, in the herein study, we noted that rats with HFHS diet-induced obesity have shown profoundly enhanced enzyme expression of COX-1, COX-2, 5-LOX, and 12/15-LOX, which are engaged in the production of various cytokines with high pro-inflammatory effects attributed to the development of local and systemic inflammatory response.