Additionally, the expression level of FMS-like tyrosine kinase-3 ligand (Flt3L) and the number of lung DCs increased significantly during the progression of pulmonary fibrosis in both mice and humans, but the accumulation of CD11b-positive cells inhibited lung fibrosis in a mouse model (Figure 2C) (128). This evidence concerns the gene ITGAM and pulmonary fibrosis.