Based on Cohn fractionation, the plasma proteins were separated with different ethanol concentrations and pH levels into five major fractions (19) as much as possible fibrinogen in Fraction I, y-globulins in Fraction II, lipid-globulins in Fraction III, α-globulins in Fraction IV, and albumins in Fraction V. Proteins extracted and purified from plasma have a wide range of therapeutic uses, including treatment for immune deficiencies, neurological diseases, autoimmune disorders, and bleeding disorders, among others (30). The gene discussed is ALB; the disease is hemorrhagic disease.