57 patients with1.In ICH, the extinction of MLH1 (+/- PMS2), or MSH2 (+/- MSH6), or MSH6, or PMS2 alone for inclusion (dMMR),2.In PCR, BAT25, BAT26, NR21, NR24, and NR27. Only tumor samples with ≥2 instable markers for inclusion (MSI-H). The gene discussed is MSH6; the disease is neoplasm.