Hepatocellular carcinoma (HCC) refers to malignant tumors of the liver, including primary and metastatic hepatocellular carcinoma, and HCC patients are often detected in peripheral mononuclear lymphocytes with a significant increase in the expression of the factors Foxp3 and RORt, which are closely related to the development of HCC, compared to normal cells (86, 87). The gene discussed is FOXP3; the disease is hepatocellular carcinoma.