STAT3 and esophageal squamous cell carcinoma: By increasing Foxp3 expression through STAT3 modification of Foxp3+Treg transcription process, activating the STAT3/Foxp3 signaling pathway within ESCC tissue hinders macrophage phagocytosis and increases Foxp3+Treg immunosuppressive activity, which helps ESCC evade the body’s immune response (26).