In colon cancer cells, Foxp3 and microRNA-155 work together to synergistically regulate the transcription of Zinc finger E-box binding homology box 2 (ZEB2), which suppresses ZEB2 expression and boosts anti-tumor immunity, reducing cancer cell growth and metastasis; In addition, Overexpression of Foxp3 also promotes MMP9 expression through the SAM cycle; The decrease of TCF-1 leads to an increase in the binding of Foxp3 to downstream gene regulatory elements, thereby promoting the expression of Treg, inhibiting the proliferation of effector T cells, and promoting the progression of CRC. This evidence concerns the gene ZEB2 and colonic neoplasm.