The binding of the lncRNA NEAT1 to the Foxp3 binding site results in high expression of its downstream target gene, pyruvate kinase PKM2, and over-expression of NEAT1/Foxp3 promotes PKM2 transcriptional activation (92), which promotes HCC proliferation by enhancing the aerobic glycolysis pathway. Here, NEAT1 is linked to hepatocellular carcinoma.