Additionally, Liu et al.’s research (85) demonstrated that Foxp3 expression was markedly down-regulated in colon cancer stem cells, that activating the Foxp3/NF-κB/COX2 pathway could prevent COX2’s transcriptional activation and impede the proliferation of colon cancer stem cells, and that Foxp3 was able to inhibit the growth of cancer cells. Here, NFKB1 is linked to malignant colon neoplasm.