FOXP3 and cancer: (96) also can confirme that Foxp3 exhibits oncogenic effects in HCC through in vitro and in vivo experiments, and Foxp3 regulates the TGF-β/smad3/4 pathway to recognize and directly or indirectly act on the Myc promoter region of oncogenes to inhibit oncogene expression; at the same time, the over-expression of Foxp3 could promote the increase of apoptotic marker Bax and expression of apoptosis inhibitor p53, which promote cancer cell apoptosis (97, 98).