FOXP3 and malignant colon neoplasm: Additionally, Liu et al.’s research (85) demonstrated that Foxp3 expression was markedly down-regulated in colon cancer stem cells, that activating the Foxp3/NF-κB/COX2 pathway could prevent COX2’s transcriptional activation and impede the proliferation of colon cancer stem cells, and that Foxp3 was able to inhibit the growth of cancer cells.