(96) also can confirme that Foxp3 exhibits oncogenic effects in HCC through in vitro and in vivo experiments, and Foxp3 regulates the TGF-β/smad3/4 pathway to recognize and directly or indirectly act on the Myc promoter region of oncogenes to inhibit oncogene expression; at the same time, the over-expression of Foxp3 could promote the increase of apoptotic marker Bax and expression of apoptosis inhibitor p53, which promote cancer cell apoptosis (97, 98). This evidence concerns the gene FOXP3 and hepatocellular carcinoma.