RIPK1 and neurodegenerative disease: In addition to its role as a critical regulator of necroptosis, RIPK1 also promotes a series of parallel detrimental signaling cascades that can induce varying degrees of neuroinflammation in neurodegenerative diseases (Zhang et al., 2013; Ransohoff, 2016; Chen et al., 2018), facilitated through various forms of ubiquitylation, deubiquitylation, and phosphorylation.