In an in situ glioma mouse model, these CAR-T cells showed potent anti-tumor activity, while immunohistochemical staining showed that CD317 was strongly and uniformly expressed in different regions of glioblastoma tissue specimens, in contrast to sections of healthy brain tissue where no or only minimal immunoreactivity was observed, while some organs in the periphery stained positively (73). This evidence concerns the gene BST2 and central nervous system cancer.