LAT and neoplasm: This cooperation between LAT and SLP-76 was applied to the design of the logic-gated intracellular network (LINK) CAR, a rapid and reversible Boolean logic and gated CAR-T cell platform that has been shown to out-perform other systems in terms of efficacy and the prevention of on-target and off-tumor toxicity, while expanding the range of molecules targeted by CAR-T cells (68).