IL6 and congenital rubella syndrome: For an in-depth study of the pathogenesis of CRS, several researchers have measured and compared the changes in IL-1β and IL-6 levels in the culture supernatants of macrophages by isolating and culturing normal human peripheral blood mononuclear macrophages, and co-incubating the culture supernatants with CAR-T cells and target cells in which GSDME was knocked out.