For instance, the most prevalent chromosomal rearrangement in acute myeloid leukemia (AML) resulting in RUNX1-RUNX1T1 fusion transcript was proposed to function as a competing endogenous RNA (ceRNA) that can cross-regulate messenger RNAs by competing for shared miRNAs, that play a crucial role in gene regulation. Here, RUNX1 is linked to acute myeloid leukemia.