B2M and neoplasm: Importantly, the risk score was significantly correlated with tumor burden (elevated LDH and β2M levels), high-risk cytogenetic abnormalities, and advanced R-ISS stages (p < 0.01), as demonstrated in Figures 5E–H.These findings highlight the significant disparities presented by a NETs-based risk score system within the prognostic factors for patients with multiple myeloma, underlining the importance of risk score in stratifying the prognosis of multiple myeloma patients.