CD8A and neoplasm: Compared with HPV- OPC, HPV+ OPC has a higher density of tumor-infiltrating lymphocytes (TILs), including CD3+ T cells, CD8+ T cells, Regulatory T cells (Treg cells), B cells, and plasma cells (Matlung et al., 2016; Gurin et al., 2020; Mito et al., 2021; Tosi et al., 2022).