MDM4 and cancer: However, together they were still not sufficient to fully recapitulate the aneuploid phenotype, suggesting that additional genes on chromosome 8 contribute to the phenotype.50 In a recent study of cancer cell lines with 1q gain, it was shown that deletion of the extra copy of MDM4 gene reduced proliferation, but not to the same extent as removing the extra copy of the entire arm.11 In human liver cancer cell lines, the loss of chromosome arm 8p leads to increased migration and invasion.