MYC and lymphoma: Expression of human MYC on chromosome 6 resulted in the additional selection of this chromosome in lymphomas.44 For the chromosome 9p monosomy that underlies defects in anti-tumor immunity, a mouse model of pancreatic cancer was used to identify the loss of type 1 interferon genes contributing to the phenotype.81 These and other studies in model organisms demonstrate that the expression changes of specific genes contribute to the selection of aneuploid chromosomes.