In HPV negative head and neck cancer (HNC) and Non-Small Cell Lung Cancer (NSCLC), the loss of chromosome arm 9p underlies a switch from an immune hot to an immune cold tumor microenvironment and serves as a predictive marker associated with limited clinical benefit from anti-PD-(L)1 therapy.54 Overall aneuploidy levels and specific aneuploidies both correlate with immune evasion and immunotherapy resistance, making aneuploidy a promising clinical prognostic biomarker for immunotherapy. Here, CD274 is linked to non-small cell lung carcinoma.