TRPV1 and bone cancer: Interestingly, a previous work showed that bone cancer rats inoculated with rat mammary gland carcinoma cells, suffered from thermal hyperalgesia and mechanical allodynia (Li et al., 2014); they also exhibited increased IGF-1 expression that triggered in DRG nociceptors upregulation of TRPV1 current density and TRPV1 protein expression (Li et al., 2014).