In the case of diabetes, hyperglycemia leads to an increase in advanced glycation end-products (AGEs) and promotes oxidative stress and inflammation, which cause vascular damages, including ASO.3) Furthermore, diabetes is associated with thrombogenic tendency, and it has also been reported that the abovementioned AGEs, C-reactive protein, and oxidated low-density lipoproteins facilitate intimal plaque rupture by producing matrix metalloproteinase-9. The gene discussed is MMP9; the disease is diabetes mellitus.