Instead, we observed the levels of IL-1β, IL-6, and TNF-α in YW002-s group and PEI-CS/YW002 group were lower than that in LPS-stimulated group, suggesting that both could inhibit the inflammatory response and achieve anti-inflammatory effects, which was also consistent with the previous results of our group.10 In the mouse periodontitis model, the application of PEI-CS/YW002 group could significantly improve the alveolar bone height of the mice, and the BV/TV and Tb.Th values were significantly increased (Fig. 6). The gene discussed is TNF; the disease is periodontitis.