MAPT and Alzheimer disease: The development of small-molecule PROTACs for tau is therefore anticipated to mitigate the toxic effects of p-tau and safeguard neurons in AD (Kargbo, 2019; Silva et al., 2019; Pradeepkiran and Reddy, 2021; Wang et al., 2021; Wang et al., 2023; Zhang et al., 2023).