NNMT and cancer: Regulation of NNMT may affect cancer-related pathways, Huang et al. (Huang et al., 2024) found through in vitro experiments that NNMT promotes the migration and invasive ability of esophageal squamous cell carcinoma (ESCC), and NNMT also promotes the process of epithelial mesenchymal transition (EMT) by affecting the post-transcriptional modification of E-calmodulin.