Curcumin can induce lethal levels of reactive oxygen species (ROS) in tumors and inhibit the activity of many enzymes involved in ROS metabolism (carboxyl reductase 1 (CBR1), Glutathione-S-transferase phi 1 (GSTP1), etc. ), promote the accumulation of ROS in tumor cells, and activate ROS-mediated mitochondrial-related apoptosis in tumor cells [48-50]. This evidence concerns the gene CBR1 and neoplasm.