In the realm of drug resistance, β-elemene alleviates gefitinib resistance in non-small cell lung cancer via mettl3-modulated autophagy [34], and opposes 5-fluorouracil resistance in p53-null colorectal cancers through autophagy-induced cell death initiation and cyclin D3-driven cell cycle arrest [35]. This evidence concerns the gene TP53 and colorectal cancer.