Low CRP levels were also useful in predicting JIA-ACR100 and JIA-ACR ID responses (Supplementary Table 3).When measured at month 4 instead of baseline, low levels of S100A8/9, S100A12, and CRP were also associated with higher odds of achieving JIA-ACR ID and JIA-ACR100 at months 16 and 21 (Supplementary Table 4). Here, S100A8 is linked to juvenile idiopathic arthritis.