A subsequent post hoc analysis revealed a similar flare risk between patients with low levels of S100A12 and CRP who were off medication and patients with JIA who continued MTX but had high levels of S100A12 and/or CRP [30, 31]; this finding suggested that S100 proteins, like CRP, are a good measure of inflammatory states in pJIA. This evidence concerns the gene CRP and juvenile idiopathic arthritis.