Early responses with combination of S100 proteins and CRP. Combined with lower CRP, lower baseline S100A8/9 and S100A12 levels were associated with even higher odds of achieving JIA-ACR ID as early as month 3 (P = 0.0010 and P = 0.0092, respectively) compared with higher S100A8/9 or S100A12 levels alone (Supplementary Table 5). Here, S100A12 is linked to juvenile idiopathic arthritis.