Whilst little is known about the functional relevance of DOK6 in obesity, other members of the DOK family are cited as susceptibility genes for obesity and diabetes in North Indian population [48] and have been linked to adipocyte hypertrophy in high-fat diet fed mice [49] [50], which may be of relevance in OA where pain severity increases with obesity [51]. Here, DOK6 is linked to obesity due to melanocortin 4 receptor deficiency.