AZIN1 and neoplasm: Moreover, while AZs have been reported to function as tumour suppressor and to negatively regulate tumour cell proliferation and transformation [71], the AZIN1 RNA editing, a post transcriptional modification that enhances its activity, has been found higher in many different cancers spanning from hepatocellular carcinomas to lung cancer and is associated to increased transformation and tumorigenesis [72, 73].