Interestingly, the basal levels of cellular ROS and lipid peroxidation were significantly increased in GCN5L1 KO cells, however, GCN5L1 deletion has been shown to promote HCC proliferation and metastasis [25, 26], therefore, GCN5L1 deletion induced lipid peroxidation was not sufficient to induce cell death but give a standby status for sorafenib-induced ferroptosis. Here, BLOC1S1 is linked to hepatocellular carcinoma.