In the macrophages, MyD88 deficiency (TLR2/4) and IRAK4 deficiency (TLR2/4) were enriched in the m7G-related macrophages, thus indicating that m7G-related macrophages were inhibited in the TLR2/4-mediated signaling pathway, which may contribute toward the development of NPC. Here, MYD88 is linked to nasopharyngeal carcinoma.