These also included Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, such as NF-κB signaling pathway, Toll-like receptor (TLR) signaling pathway, NK cell-mediated cytotoxicity, and EBV infection (Supplementary Fig. S1E), which suggests a strong antiviral response in patients with NPC. This evidence concerns the gene NFKB1 and Epstein-Barr virus infection.