DLBCL with rearrangements of MYC, BCL2, and/or BCL6, known as “double-hit lymphoma” (DHL), has been defined as a new entity and renamed “high-grade B-cell lymphoma (HGBCL) with rearrangements of MYC and BCL2 and/or BCL6” [3, 4]. The gene discussed is BCL6; the disease is diffuse large B-cell lymphoma.