DLBCL with rearrangements of MYC, BCL2, and/or BCL6, known as “double-hit lymphoma” (DHL), has been defined as a new entity and renamed “high-grade B-cell lymphoma (HGBCL) with rearrangements of MYC and BCL2 and/or BCL6” [3, 4]. This evidence concerns the gene BCL6 and B-cell non-Hodgkin lymphoma.