Through RNA-seq analysis, we found that brequinar could affect a broad range of genes at the transcriptional level, including genes involved in the DNA damage repair signaling pathway (PIM1, PIM2, MDC1, CHEK1, and CHEK2) and those mutated in DLBCL patients (SNHG5, FBXW8, CDKN2A, etc.)[41–43]. Here, CHEK2 is linked to diffuse large B-cell lymphoma.