FBXO2 and posterior cortical atrophy: We selected E3 ligome (Fig. 2A) and DUBome (Fig. 2B, Additional file 7: Table S4) in PCa proteome and found five significantly downregulated proteins, including E3 ligases PJA2, ZNF451, FBXO2 and DCAF10, and deubiquitinase UCHL1 (Fig. 2C and G).