We selected E3 ligome (Fig. 2A) and DUBome (Fig. 2B, Additional file 7: Table S4) in PCa proteome and found five significantly downregulated proteins, including E3 ligases PJA2, ZNF451, FBXO2 and DCAF10, and deubiquitinase UCHL1 (Fig. 2C and G). Here, UCHL1 is linked to posterior cortical atrophy.