Overall, there are no known interacting partners for E3 ligases PJA2, ZNF451, FBXO2, DCAF10, and DUB UCHL1 in our csDEPs due to the limitation of samples and technology (Fig. 1F), but this phenomenon does not mean that down-regulated UCHL1, PJA2, ZNF451, FBXO2, and DCAF10 have no effects on proteostasis in PCa. The gene discussed is ZNF451; the disease is posterior cortical atrophy.